The Bed
Gran Meliá Colón
Calle de Canalejas 1; +34-954-50-55-99
The crown jewel of Seville's hotels dates back to the 13th century -- when it served as a convent -- and honors its deeply rooted history in the city's bullfighting tradition. The newly renovated and modernized rooms mix classic Spanish architecture with furniture by Philippe Starck and Marcel Wanders.

Eme
Calle de los Alemanes 27, +34-954-56-00-00
Located across the street from the Cathedral and its famous Giralda bell tower, the over-the-top modern aesthetic of the 60-room Eme contrasts a sleek design with its classic Sevillian architecture.

The Morning After
For a day of shopping, stroll along Calle Sierpes, Calle de Velázquez, and Calle Tetuán for affordable threads from Spanish brands like Mango, Bershka, Pull and Bear, Zara, and Massimo Dutti. For something a little more high-end, visit the designer boutiques in Plaza Nueva -- especially Purificación Garcia, for classic European styles you won't find back home.

The Flight
Iberia Business Plus
800-772-4642
With two direct flights from JFK to Madrid each day, cushy seats that recline into beds, menus designed by chef Sergi Arola, and a wine list of Spain's finest Riojas, the long haul to Spain won't leave you with coach-class jet lag.

Part One | Part Two